This article proposes three states in an actor-network and a global/local distinction among actants. This theoretical framework is applied to two invention networks: one created by an inventor of solar heating systems and another created by a designer who wanted to create an environmentally sustainable furniture fabric. Both solar inventor and fabric designer wanted to develop technologies that would improve the environment and also make money. The article concludes by considering whether invention networks that intend to turn “good into gold” (...) have to evolve a shared representation or whether it is sufficient for a new design to serve as a boundary object for actants. (shrink)

The Elements of Philosophy: Readings from Past and Present offers an extensive collection of classic and contemporary readings, organized topically into five main sections: Religion and Belief, Moral and Political Philosophy, Metaphysics and Epistemology, Philosophy of Mind and Language, and Life and Death. Within these broad areas, readings are arranged in clusters that address both traditional issues--such as the existence of God, justice and the state, knowledge and skepticism, and free will--and contemporary topics--including God and science, just war theory, vegetarianism, (...) and time travel. Carefully chosen selections from a wide range of pre-20th-century philosophers are paired with writings from more than fifty leading contemporary philosophers and thinkers. The traditional philosophers represented range from Plato and Aristotle to Immanuel Kant and A.J. Ayer; the contemporary philosophers include Saul Kripke, David Lewis, Thomas Nagel, Derek Parfit, Hilary Putnam, Robert Nozick, Judith Jarvis Thomson, John Rawls, Bernard Williams, and Susan Wolf. Also included are selections from linguist Noam Chomsky, physicist Albert Einstein, and psychologist William James. Edited by a team of scholars who are also highly esteemed instructors, The Elements of Philosophy is uniquely student-friendly. A team of undergraduate philosophy majors played a central role in helping to select topics, choose readings, and identify terms likely to require clarification. In response to their suggestions, the volume includes detailed introductions to each section, explanatory footnotes that define unfamiliar terms and concepts, an extensive glossary, and a guide to further resources. A companion Instructor's Manual, available on CD, offers article summaries, suggested essay questions, reading guides, model handouts, and sample syllabi. One of the most extensive and expansive anthologies available, The Elements of Philosophy is an ideal choice for both general and targeted introductory philosophy courses. (shrink)

W.M. Gorman has been a major figure in the development of economies during the past forty years. His publications on separability, aggregation, duality and the modelling of consumer demand are recognized as fundamental contributions to economic theory. Many of his unpublished papers have achieved similar status as privately-circulated classics.This volume brings together for the first time all Gorman's important work, much of which has never been published before, on aggregation across commodities and agents, including separability, budgeting, representative agents, (...) and the construction of capital and labour aggregates. Each chapter is preceded by an editorial introduction which describes its origin and place within the literature as well as the main results themselves. A forthcoming second volume, Modelling and Methodology, will cover topics on duality, demand, trade, and welfare.This book will appeal to academic economists interested in either specific aspects of Gorman's work or in the evolution of economic theory. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Theory of Belief Michael M. Gorman Belief is a key concept in Hume's philosophy, and yet Hume's statements aboutbeliefappear to be hopelesslyinconsistent.1 Various solutions have been offered, from saying that Hume is incorrigibly confused to saying that his theory ofbeliefchanged over the course of his career. This article will focus on the question ofthe nature ofbelief and show that Hume's theory is in fact consistent. In sections (...) 1 and 2, I will separate those passages where Hume discusses the nature of beUeffrom those where he discusses other questions. In sections 3-6, 1 will examine his theory ofthe nature ofbelief. Finally, in section 7, 1 will briefly look at his theories on other questions concerning belief. 1.Hume's statements about belief can be divided into at least nine different categories. Hume says that a beliefis: 1.an idea conceived in a certain manner (e.g., E 49, T 96); 2.that certain manner ofconception itself(e.g., E 49, T 97); 3.an idea that feels a certain way (e.g., E 48, T 103); 4.that certain feeling itself(e.g., E 49, T 624, 629); 5.an idea that has a great influence on the mind (e.g, T 118-20); 6.an act ofmind rendering realities influential on the mind (e.g., E 49, T 629); 7.a lively idea related to an impression (e.g., T 96); 8.a lively manner of conceiving an idea, which manner arises from an impression (e.g., E 50); 9.something that makes ideas forceful and vivacious (e.g., T 101, 627). If one were in a really bad mood, one could probably split Hume's formulations into even more categories.2 2.One solution wouldbe to saythat Hume ishopelessly confused.3 This is not accurate, however. The first thingtobe done is to notice thatonly the statements belonging to the first four categories are actually answers to the question, What is the nature of beUef? Hume tells us that abeUefis: an ideaconceived in acertainmanner, theverymanner ofconception ofsuch an idea, an idea thatfeels a certain way, thevery feeling of such an idea. To explicate Hume's theory of the nature of Volume XLX Number 1 89 MICHAEL M. GORMAN beUef, I will show that the second formulation is a poor version ofthe first and that the fourth formulation is a poor version ofthe third—in other words, that there are reallyonlytwo theorieshere, notfour. Then I will reconcile these two theories. As for Hume's discussion ofother questions concerning belief, the statementsin the fifth and sixth categories address the question, What does à belief do? Those in the seventh and eighth categories take for granted the statements in the first and second categories respectively and address the further question, What causes beliefs? Those in the ninth category are probably cases of bad writing. All these will be examined in section 7. 3. Let us look at the texts that fit into the first and second categories listed in section 1. These express what can be called Hume's "manner-of-conception theory" (MCT). First, Hume says that a belief is a certain kind ofidea, namely an idea conceived in a certain manner. He describes this manner ofconception by saying that such an idea is conceived with a high degree of force and vivacity, liveliness, and so forth. This analysis rests on Hume's distinction between the content of an idea and the manner in which the idea is conceived. [A]s 'tis certain there is a great difference betwixt the simple conception ofthe existence ofan object, and the beliefofit, and as this difference lies not in the parts or composition of the idea, which we conceive; it follows, that it must lie in the manner, in which we conceive it. (T 94-95) One can believe that something is the case, or one can simply conceive ofits being the case without assenting to it. In both cases, Hume says, the content ofthe idea must be the same. Otherwise, both making up one's mind and disagreeingwith someone wouldbe impossible: making up one's mind would be a transition from thinking about one thing to thinking about... (shrink)

Psychedelic Harm Reduction and Integration is a transtheoretical and transdiagnostic clinical approach to working with patients who are using or considering using psychedelics in any context. The ongoing discussion of psychedelics in academic research and mainstream media, coupled with recent law enforcement deprioritization of psychedelics and compassionate use approvals for psychedelic-assisted therapy, make this model exceedingly timely. Given the prevalence of psychedelic use, the therapeutic potential of psychedelics, and the unique cultural and historical context in which psychedelics are placed, it (...) is important that mental health providers have an understanding of the unique motivations, experiences, and needs of people who use them. PHRI incorporates elements of harm reduction psychotherapy and psychedelic-assisted psychotherapy, and can be applied in both brief and ongoing psychotherapy interactions. PHRI represents a shift away from assessment limited to untoward outcomes of psychedelic use and abstinence-based addiction treatment paradigms and toward a stance of compassionate, destigmatizing acceptance of patients' choices. Considerations for assessment, preparation, and working with difficult experiences are presented. (shrink)

This book describes empirically ways to analyze and then to effectually utilize cognitive processes to advance discovery and invention in the sciences. It also explains how to teach these principles to students.

Why do some parents refuse to vaccinate their children? Why do some people keep guns at home, despite scientific evidence of risk to their family members? And why do people use antibiotics for illnesses they cannot possibly alleviate? When it comes to health, many people insist that science is wrong, that the evidence is incomplete, and that unidentified hazards lurk everywhere. In Denying to the Grave, Gorman and Gorman, a father-daughter team, explore the psychology of health science denial. (...) Using several examples of such denial as test cases, they propose six key principles that may lead individuals to reject "accepted" health-related wisdom: the charismatic leader; fear of complexity; confirmation bias and the internet; fear of corporate and government conspiracies; causality and filling the ignorance gap; and the nature of risk prediction. The authors argue that the health sciences are especially vulnerable to our innate resistance to integrate new concepts with pre-existing beliefs. This psychological difficulty of incorporating new information is on the cutting edge of neuroscience research, as scientists continue to identify brain responses to new information that reveal deep-seated, innate discomfort with changing our minds. Denying to the Grave explores risk theory and how people make decisions about what is best for them and their loved ones, in an effort to better understand how people think when faced with significant health decisions. This book points the way to a new and important understanding of how science should be conveyed to the public in order to save lives with existing knowledge and technology. (shrink)

Although data sharing is one of the primary measures proposed to improve the integrity and quality of published research, studies show it remains the exception not the rule. The current study examines the availability of data in papers reporting the results of analyses of empirical data from original research in high-impact addiction journals. Thirteen high-impact journals with data sharing policies were selected from those included in the substance abuse category of the 2018 Clarivate Analytics’ Journal Citation Report. The first 10 (...) full or short original research reports that included empirical data in the most recent complete issue of each journal were electronically searched and reviewed for reference to where their data can be obtained and for a formal data sharing statement. Only eight of the 130 papers contained a data sharing statement in their text or supplementary online materials, and just one contained a direct link to the data analyzed. Data sharing was rare in the 13 high-impact addiction journals reviewed. The nature of the data reported in addiction journals might partly explain this. Currently, data sharing is not a procedure likely to improve the quality and integrity of published addiction research. (shrink)

Concern about the integrity of empirical research has arisen in recent years in the light of studies showing the vast majority of publications in academic journals report positive results, many of these results are false and cannot be replicated, and many positive results are the product of data dredging and the application of flexible data analysis practices coupled with selective reporting. While a number of potential solutions have been proposed, the effects of these are poorly understood and empirical evaluation of (...) each would take many years. We propose that methods from the systems sciences be used to assess the effects, both positive and negative, of proposed solutions to the problem of declining research integrity such as study registration, Registered Reports, and open access to methods and data. In order to illustrate the potential application of systems science methods to the study of research integrity, we describe three broad types of models: one built on the characteristics of specific academic disciplines; one a diffusion of research norms model conceptualizing researchers as susceptible, “infected” and recovered; and one conceptualizing publications as a product produced by an industry comprised of academics who respond to incentives and disincentives. (shrink)

The Elements of Philosophy: Readings from Past and Present is a comprehensive collection of historical and contemporary readings across the major fields of philosophy. With depth and quality, this introductory anthology offers a selection of readings that is both extensive and expansive; the readings span twenty-five centuries. They are organized topically into five parts: Religion and Belief, Moral and Political Philosophy, Metaphysics and Epistemology, Philosophy of Mind and Language, and Life and Death. The product of the collaboration of three highly (...) respected scholars in their fields - Tamar Szabó Gendler, Susanna Siegel, and Steven M. Cahn - The Elements of Philosophy also includes introductions from the editors, explanatory footnotes, and a glossary. (shrink)

This article presents a framework for practitioners who may be interested in maintaining adaptive stability of sociotechnical networks. The framework is developed from assembling several concepts that are useful for assessing and for drawing on appropriate moral reasoning strategies as sociotechnical networks are designed, constructed, and adapted. One such strategy involves the ability to assess degrees of perspective sharing and trading relationships in networks using moral imagination. The article uses the case of the design of an environmentally sustainable fabric to (...) illustrate these strategic concepts. The framework also draws on other examples of cases in which sociotechnical networks have become destabilized to illustrate instances in which the framework may have been useful for decreasing a tendency for destabilization. (shrink)

ObjectiveMost young adults diagnosed with breast or gynecologic cancers experience adverse reproductive or sexual health outcomes due to cancer and its treatment. However, evidence-based interventions that specifically address the RSH concerns of young adult and/or LGBTQ+ survivor couples are lacking. Our goal is to develop a feasible and acceptable couple-based intervention to reduce reproductive and sexual distress experience by young adult breast and gynecologic cancer survivor couples with diverse backgrounds.MethodsWe systematically adapted an empirically supported, theoretically grounded couple-based intervention to address (...) the RSH concerns of young couples coping with breast or gynecologic cancer through integration of stakeholder perspectives. We interviewed 11 couples with a history of breast or gynecologic cancer to review and pretest intervention materials. Three of these couples were invited to review and comment on intervention modifications. Content experts in RSH and dyadic coping, clinicians, and community advisors participated throughout the adaptation process.ResultsFindings confirmed the need for an online, couple-based intervention to support young couples experiencing RSH concerns after breast or gynecologic cancer. Qualitative themes suggested intervention preferences for: A highly flexible intervention that can be tailored to couples’ specific RSH concerns; Active steps to help members of a dyad “get on the same page” in their relationship and family building plans; A specific focus on raising partners’ awareness about how cancer can affect body image and physical intimacy; and Accessible, evidence-based information about RSH for both partners. These results, along with feedback from stakeholders, informed adaptation and finalization of the intervention content and format. The resulting virtual intervention, Opening the Conversation, includes five weekly sessions offering training to couples in communication and dyadic coping skills for addressing RSH concerns.ConclusionThe systematic adaptation process yielded a theory-informed intervention for young adult couples facing breast and gynecological cancers, which will be evaluated in a randomized controlled trial. The long-term goal is to implement and disseminate Opening the Conversation broadly to reach young adult couples with diverse backgrounds who are experiencing RSH concerns in cancer survivorship. (shrink)

This dissertation is an investigation of ontological priority. The Introduction argues that although philosophers have often been concerned with the things that are ontologically prior, they have seldom addressed the question of what ontological priority is. ;Part One gives a detailed analysis of what ontological priority is. Chapter 1 notes that there are two competing theories available: according to the first, ontological priority is a dependence relation; according to the second, it is a degrees-of-being relation. Since the two views are (...) in themselves irreconcilable and since there are no good grounds for choosing between them, it is better to find a "higher" theory that encompasses both of them. Chapter 2 lays the groundwork for the development of this "higher" theory by examining the Scotistic notion of "essential order", a notion that includes the two relations that have been called 'ontological priority' as noted in Chapter 1. Chapter 3 adapts Scotus's understanding of essential order to formulate a definition of ontological priority. The definition does not define just one relation; rather, it gives membership criteria for an entire class of "ontological priority relations". ;Part Two examines some of the members of the class of ontological priority relations. Chapter 4 examines dependence and concludes three things: first, that the received understanding of dependence is incorrect; second, that dependence properly understood is an ontological priority relation; third, that the relation that is usually thought to be dependence is also an ontological priority relation. Chapter 5 examines degrees-of-being. Since the question of what degrees-of-being is is too complicated to deal with in the context of the dissertation, the chapter examines several theories and shows that degrees-of-being is an ontological priority relation according to any of the theories. ;The Conclusion shows some relations among the three ontological priority relations discussed in Part Two. It also shows briefly how the concept of ontological priority relations can be used to talk about the orderings of the universe. Finally, it points the way to further investigation. (shrink)

The philosophical literature understands ontological priority in two ways, in terms of dependence, and in terms of degrees-of-being. These views are not reconcilable in any straightforward manner. However, they can be reconciled indirectly, if both are seen as instances of higher-level concept that is a modification of John Duns Scotus' notion of essential order. The result is a theory of ontological priority that takes the form of a list of membership criteria for the class of "ontological priority relations", of which (...) dependence and degrees-of-being are just two examples. (shrink)

In this reply to Paul Simmons, it is argued that while biblical scripture should be understood as the Christian's first and final authority, it is appropriate to draw on other writings as sources for moral reflection. Responsible biblical interpretation and theological reflection must include careful historical analysis. It is inaccurate and anachronistic to read into early Jewish and Christian thinkers a position much like the reigning secular philosophical-legal position on abortion, where fetal non-personhood and individual freedom results in abortion without (...) legal constraints. Careful scholarship reveals that a theological community-based Christian ethic, which develops from first century reflections and biblical canonical authority, prohibits direct abortion as an option for the Christian community. (shrink)

Betrifft die Handschriften Codd. 12, 13 (S. 185), 134 (S. 181, 332, 336-337), 224 (S. 173), 325 (S. 246), 352 (S. 185), 540 (S. 113, 211) und A 91.8 (S. 2-3, 168, 177, 320, 328, 354) der Burgerbibliothek Bern.

This article describes the UniversAAL platform, an open platform intended to facilitate the development, distribution, and deployment of technological solutions for Ambient assisted living. The platform is intended to benefit end users, authorities with responsibility for AAL, and organizations involved in the development and deployment of AAL services. It consists of an extensive set of resources aimed at these different groups. The resources are classified into three main groups: runtime support, development support, and community support. The article presents the benefits (...) that can be expected from the widespread adoption of the platform. The article also describes progress on prototype implementations of some of the software resources, and the results of initial evaluations of the platform. The work is partially based on results from earlier European Union-funded research projects in the area. (shrink)

BackgroundThe rigor and integrity of the published research in nutrition studies has come into serious question in recent years. Concerns focus on the use of flexible data analysis practices and selective reporting and the failure of peer review journals to identify and correct these practices. In response, it has been proposed that journals employ editorial procedures designed to improve the transparency of published research.ObjectiveThe present study examines the adoption of editorial procedures designed to improve the reporting of empirical studies in (...) the field of nutrition and dietetics research.DesignThe instructions for authors of 43 journals included in Quartiles 1 and 2 of the Clarivate Analytics’ 2018 Journal Citation Report category Nutrition and Dietetics were reviewed. For journals that published original research, conflict of interest disclosure, recommendation of reporting guidelines, registration of clinical trials, registration of other types of studies, encouraging data sharing, and use of the Registered Reports were assessed. For journals that only published reviews, all of the procedures except clinical trial registration were assessed.ResultsThirty-three journals published original research and 10 published only reviews. Conflict of interest disclosure was required by all 33 original research journals. Use of guidelines, trial registration and encouragement of data sharing were mentioned by 30, 27 and 25 journals, respectively. Registration of other studies was required by eight and none offered Registered Reports as a publication option at the time of the review. All 10 review journals required conflict of interest disclosure, four recommended data sharing and three the use of guidelines. None mentioned the other two procedures.ConclusionsWhile nutrition journals have adopted a number of procedures designed to improve the reporting of research findings, their limited effects likely result from the mechanisms through which they influence analytic flexibility and selective reporting and the extent to which they are properly implemented and enforced by journals. (shrink)

This article investigates whether acts of plagiarism are predictable. Through a deductive, quantitative method, this study examines 517 students and their motivation and intention to plagiarize. More specifically, this study uses an ethical theoretical framework called the Theory of Reasoned Action and Planned Behavior to proffer five hypotheses about cognitive, relational, and social processing relevant to ethical decision making. Data results indicate that although most respondents reported that plagiarism was wrong, students with strong intentions to plagiarize had a more positive (...) attitude toward plagiarizing, believed that it was important that family and friends think plagiarizing is acceptable, and perceived that plagiarizing would be an easy task. However, participants in the current study with less intention to plagiarize hold negative views about plagiarism, do not believe that plagiarism is acceptable to family, friends or peers, and perceive that the act of plagiarizing would prove difficult. Based on these findings, this study considers implications important for faculty, librarians, and student support staff in preventing plagiarism through collaborations and outreach programming. (shrink)

The development of any novel reproductive technology involving manipulation of human embryos is almost inevitably going to be controversial and evoke sincerely held, but diametrically opposing views. The plethora of scientific, ethical and legal issues that surround the clinical use of such techniques fuels this divergence of opinion. During the policy change that was required to allow the use of mitochondrial donation in the UK, many of these issues were intensely scrutinised by a variety of people and in multiple contexts. (...) This extensive process resulted in the publication of several reports that informed the recommendations made to government. We have been intrinsically involved in the development of mitochondrial donation, from refining the basic technique for use in human embryos through to clinical service delivery, and have taken the opportunity in this article to offer our own perspective on the issues it raises. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

At the forefront of international concerns about global legislation and regulation, a host of noted environmentalists and business ethicists examine ethical issues in consumption from the points of view of environmental sustainability, economic development, and free enterprise.

Noting the pervasiveness of the adoption of "responsibility" as a core ideal of neoliberal governance, the contributors to Competing Responsibilities challenge contemporary understandings and critiques of that concept in political, social, and ethical life. They reveal that neoliberalism's reification of the responsible subject masks the myriad forms of individual and collective responsibility that people engage with in their everyday lives, from accountability, self-sufficiency, and prudence to care, obligation, and culpability. The essays—which combine social theory with ethnographic research from Europe, North (...) America, Africa, and New Zealand—address a wide range of topics, including critiques of corporate social responsibility practices; the relationships between public and private responsibilities in the context of state violence; the tension between calls on individuals and imperatives to groups to prevent the transmission of HIV; audit culture; and how health is cast as a citizenship issue. Competing Responsibilities allows for the examination of modes of responsibility that extend, challenge, or coexist with the neoliberal focus on the individual cultivation of the self. Contributors Barry D. Adam, Elizabeth Anne Davis, Filippa Lentzos, Jessica Robbins-Ruszkowski, Nikolas Rose, Rosalind Shaw, Cris Shore, Jessica M. Smith, Susanna Trnka, Catherine Trundle, Jarrett Zigon. (shrink)

Background: Emergency exception to informed consent regulation was introduced to provide a venue to perform research on subjects in emergency situations before obtaining informed consent. For a study to proceed, institutional review boards need to determine if the regulations have been met.Aim: To determine IRB members’ experience reviewing research protocols using emergency exception to informed consent.Methods: This qualitative research used semistructured telephone interviews of 10 selected IRB members from around the US in the fall of 2003. IRB members were chosen (...) as little is known about their views of exception to consent, and part of their mandate is the protection of human subjects in research. Interview questions focused on the length of review process, ethical and legal considerations, training provided to IRB members on the regulations, and experience using community consultation and notification. Content analysis was performed on the transcripts of interviews. To ensure validity, data analysis was performed by individuals with varying backgrounds: three emergency physicians, an IRB member and a layperson.Results: Respondents noted that: emergency exception to informed consent studies require lengthy review; community consultation and notification regulations are vague and hard to implement; current regulations, if applied correctly, protect human subjects; legal counsel is an important aspect of reviewing exception to informed-consent protocols; and IRB members have had little or no formal training in these regulations, but are able to access materials needed to review such protocols.Conclusions: This preliminary study suggests that IRB members find emergency exception to informed consent studies take longer to review than other protocols, and that community consultation and community notification are the most difficult aspect of the regulations with which to comply but that they adequately protect human subjects. (shrink)

In this paper, I describe and criticize M.G.F. Martin's version of disjunctivism, and his argument for it from premises about self-knowledge.

This book celebrates the work of Patricia Werhane, an iconic figure in business ethics. This festschrift is a collection of articles that build on Werhane’s contributions to business ethics in such areas as Employee Rights, the Legacy of Adam Smith, Moral Imagination, Women in Business, the development of the field of business ethics, and her contributions to such fields as Health Care, Education, Teaching, and Philosophy. All papers are new contributions to the management literature written by well-known business ethicists, such (...) as Norman Bowie, Richard De George, Ronald Duska, Edwin Hartman, Michael Hoffman, Mollie Painter-Morland, Mark Schwartz, Andrew Wicks, and others. The volume is comprised of articles that reflect on Werhane’s work as well as build on it as a way to advance further research. At the end of the festschrift, Pat Werhane provides responses to each chapter. The first chapter of the book also includes the overview of Patricia Werhane’s work and her academic career. The book is written to appeal to management scholars and graduate students interested in the areas of Business Ethics, Modern Capitalism, and Human Rights. Patricia Werhane is one of the most distinguished figures in the field of business ethics. She was a founder of the field, she is one of its leading scholars, and she has had a profound impact on the world of business practice. Among her many accomplishments, Pat is known for her original work on moral imagination, she is an acclaimed authority on employee rights in the workplace, and she is one of the leading scholars on Adam Smith. Having been active in Academia for over 50 years, Werhane is a prolific author of over a hundred articles and book chapters, and the author or editor of twenty-seven books, including Adam Smith and his Legacy for Modern Capitalism, Moral Imagination and Management Decision-Making, and co-authored books Organization Ethics in Health Care, Alleviating Poverty Through Profitable Partnerships, Obstacles to Ethical Decision-Making, Corporate Responsibility: The American Experience, and Research Approaches to Business Ethics and Corporate Responsibility. (shrink)

Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (...) (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. (shrink)